NAFTIFENE HYDROCHLORIDE
Naftifine hydrochloride
CAS: 65473-14-5
Molecular Formula: C21H22ClN
NAFTIFENE HYDROCHLORIDE - Names and Identifiers
| Name | Naftifine hydrochloride |
| Synonyms | NAFTINE HCL NAFTIFINE HCL Naftifine HCl NAFTIFENE HYDROCHLORIDE NAFTIFINE HYDROCHLORIDE Naftifine hydrochloride Naftifine hyrdrochloride Exoderil, Naftin, Suadian, Naftifine Hydrochloride (200 mg) (E)-N-Cinnamyl-N-methyl(1-naphthylmethyl)amine hydrochloride N-TRANS-CINNAMYL-N-METHYL-(1-NAPHTHYLMETHYL)AMINE HYDROCHLORIDE |
| CAS | 65473-14-5 |
| EINECS | 620-502-9 |
| InChI | InChI=1/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+ |
NAFTIFENE HYDROCHLORIDE - Physico-chemical Properties
| Molecular Formula | C21H22ClN |
| Molar Mass | 323.86 |
| Melting Point | 172-175°C |
| Boling Point | 440.1 °C at 760 mmHg |
| Solubility | ethanol: soluble 50 mg/mL |
| Appearance | White or white-like crystalline powder |
| Color | White to Off-White |
| Merck | 14,6355 |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| MDL | MFCD00059047 |
| Use | Used as an antibiotic |
NAFTIFENE HYDROCHLORIDE - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | nwg |
| RTECS | QJ8650000 |
| HS Code | 29214990 |
NAFTIFENE HYDROCHLORIDE - Standard
Authoritative Data Verified Data
This product is (E)-N-methyl-N-(3-phenyl-2-propenyl)-1-naphthylmethylamine hydrochloride. The content of C21H21N • HCl shall not be less than 99.0% calculated on a dry basis.
Last Update：2024-01-02 23:10:35
NAFTIFENE HYDROCHLORIDE - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline powder; Odorless.
- This product is soluble in methanol and chloroform, and is almost insoluble in water.
melting point
The melting point of this product (General 0612) is 175~180 *
Last Update：2022-01-01 15:33:52
NAFTIFENE HYDROCHLORIDE - Introduction
Naftifine, Hydrochloride is an antifungal agent.
Last Update：2022-10-16 17:27:45
NAFTIFENE HYDROCHLORIDE - Differential diagnosis
Authoritative Data Verified Data
- take this product, dissolve and dilute with ethanol to make a solution containing about 10ug per lml, and measure by UV-Vis spectrophotometry (General 0401), there is a maximum absorption at the wavelength of 223nm and 254nm.
- The infrared absorption spectrum of this product should be consistent with that of the reference product (General rule 0402).
- this product of methanol solution chloride identification (1) of the reaction (General 0301).
Last Update：2022-01-01 15:33:52
NAFTIFENE HYDROCHLORIDE - Exam
Authoritative Data Verified Data
Related substances
take this product, add methanol to dissolve and dilute to make a solution containing about 2mg per 1 ml, as a test solution; Take appropriate amount of precision, A solution containing 20ug per 1 ml was prepared as a control solution by quantitative dilution with toluene. According to the test of high performance liquid chromatography (General rule 0512), silica gel bonded with eighteen alkyl silane is used as the filler, and ammonium acetate solution (1.154g of ammonium acetate is taken, 0.2 of water is added to dissolve it, of glacial acetic acid is added)-Methanol (30:70) as mobile phase with detection wavelength at 254nm. The number of theoretical plates is not less than 2000 based on the calculation of naftifine peak. The LOLs of the test solution and the control solution were respectively injected into the human liquid chromatograph, and the chromatogram was recorded to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of ignition residue shall not contain more than 20 parts per million of heavy metal after examination by law (General rule 0821, Law II).
arsenic salt
take l.Og of this product, add 5ml of hydrochloric acid and 20ml of water to dissolve, check according to law (General rule 0822 first law), should comply with the provisions (0.0002%).
Last Update：2022-01-01 15:33:53
NAFTIFENE HYDROCHLORIDE - Content determination
Authoritative Data Verified Data
take this product about 0.25g, precision weighing, add glacial acetic acid 10ml and acetic anhydride 30ml dissolved, according to the potential titration method (General rule 0701), with perchloric acid titration solution (0.1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml perchloric acid titration solution (0.1 mol /L) corresponds to 32.39mg of C21H21N-HCl.
Last Update：2022-01-01 15:33:53
NAFTIFENE HYDROCHLORIDE - Category
Authoritative Data Verified Data
antifungal drugs.
Last Update：2022-01-01 15:33:53
NAFTIFENE HYDROCHLORIDE - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 15:33:53
NAFTIFENE HYDROCHLORIDE - Naftifine hydrochloride ointment
Authoritative Data Verified Data
This product contains naftifine hydrochloride (C21H21N • HCl) should be 90.0% ~ 110.0% of the label amount.
trait
This product is white ointment.
identification
In the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the control solution.
examination
should comply with the relevant provisions under ointment (General rule 0109).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system applicability test using eighteen alkyl silane bonded silica gel as filler; Ammonium acetate solution (1.154g of ammonium acetate, 300ml of water, 0.2ml of glacial acetic acid, Shake)-Methanol (30:70) as mobile phase; The detection wavelength was 254nm. The number of theoretical plates is not less than 2000 based on the calculation of naftifine peak.
- determination method: take an appropriate amount of this product (about 4mg equivalent to naftifine hydrochloride), weigh it accurately, put it in a 50ml measuring flask, add about 30ml of methanol, and sonicate it to dissolve naftifine hydrochloride, cool, dilute to the scale with methanol, shake, filter, take the filtrate as the test solution, take the LOL injection liquid chromatograph with precision, record the chromatogram; another naftifine hydrochloride reference substance was carefully weighed, dissolved with methanol and quantitatively diluted to prepare a solution containing about 80ug per 1 ml, which was determined by the same method and calculated by peak area according to external standard method.
category
Same as naftifine hydrochloride.
specification
10g:0.lg
storage
shade, seal, and store in a cool place.
Last Update：2022-01-01 15:33:54
NAFTIFENE HYDROCHLORIDE - Naftifine hydrochloride solution
Authoritative Data Verified Data
This product contains naftifine hydrochloride (C21H21N • HCl) should be 90.0% ~ 110.0% of the label amount.
trait
This product is a colorless clear liquid.
identification
In the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the control solution.
examination
- the amount of ethanol should be 14% to 18% (General 0711).
- others shall be in accordance with the relevant provisions under the item of paint (General rule 0118).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system applicability test using eighteen alkyl silane bonded silica gel as filler; Ammonium acetate solution (take 1.154g of ammonium acetate, add 300ml of water to dissolve it, add 0.2ml of glacial acetic acid, shake well)-Methanol (30:70) as mobile phase; The detection wavelength was 254nm. The number of theoretical plates is not less than 2000 based on the calculation of naftifine peak.
- determination precision: take an appropriate amount of this product and quantitatively dilute it with methanol to prepare a solution containing about 80ug of naftifine hydrochloride per 1 ml as a test solution, lOul was injected into human liquid chromatograph accurately, and the chromatogram was recorded. Another reference substance of naftifine hydrochloride was taken, dissolve and quantitatively dilute with methanol to prepare a solution containing about 80ug of naftifine hydrochloride per 1 ml, which is determined by the same method and calculated by peak area according to external standard method.
category
Same as naftifine hydrochloride.
specification
10ml: O.lg
storage
shade, close, and store in a cool place.
Last Update：2022-01-01 15:33:55
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